Post: #1

I don't see this as a great cure that suddenly turns bored housewives into nymphomaniacs with eyes only for their husbands. It looks like it's just another anti-depressant, but with better marketing.

It took a renewed lobbying campaign that pushed the lack of options to treat women's sexual disorders to overcome two previous rejections by the FDA.

http://www.theguardian.com/business/2015...erin-addyi

Quote:The FDA has finally approved the little pink pill to help women boost their sex drive.

Flibanserin, to be sold as Addyi, finally got a green light from the US Food and Drug Administration on Tuesday. This was the third time the agency has considered approval for the drug, which is intended for women diagnosed with hypoactive sexual desire disorder, HSDD.

The drug, while often referred to as “female Viagra”, is more akin to an antidepressant as it changes brain chemistry similar to the way that dopamine and serotonin do. Viagra relaxes muscles and increases blood flow to particular areas of the male body, helping treat erectile disfunction. While the blue pill for men should be taken before engaging in sexual activity, women are to take the pink pill daily.

“Today’s approval provides women distressed by their low sexual desire with an approved treatment option,” said Janet Woodcock, M.D., director of the FDA’s Center for Drug Evaluation and Research (CDER). “The FDA strives to protect and advance the health of women, and we are committed to supporting the development of safe and effective treatments for female sexual dysfunction.”

But the FDA cautioned that care should be taken for potential adverse reactions to the pill, including low blood pressure and loss of consciousness.

“Because of a potentially serious interaction with alcohol, treatment with Addyi will only be available through certified health care professionals and certified pharmacies,” Woodcock said. “Patients and prescribers should fully understand the risks associated with the use of Addyi before considering treatment.”

In June of this year, the pill took the first step to making it into US pharmacies. An FDA panel voted 18-6 in favor of approving Flibanserin on the condition that Sprout develops a plan to limit safety risks. The panel had previously rejected the pill twice before.

When the FDA rejected Boehringer Ingelheim’s application for Flibanserin in June of 2010, it ruled that the drug worked no better than a placebo.

“I certainly hope Boehringer doesn’t give up,” Sheryl A Kingsberg, a psychologist and Case Western Reserve University medical professor, told the New York Times at that time. “Flibanserin showed an awful lot of promise. I’m going to have some very, very disappointed patients if there’s nothing for them.”

Yet by October of that year, Boehringer did just that, announcing that it was discontinuing development of Flibanserin. Months later, in 2011, the drug was acquired by Sprout. The pharmaceutical company tried its luck before the FDA in June of 2013, only to be thwarted when the agency ruled that the risks of sleepiness, dizziness, fatigue and nausea outweighed the benefits.

It was at about that time that the conversation about Flibanserin became heated, with opponents lobbying against the drug due to its side effects and supporters accusing the FDA of gender bias.

In October of last year, Sprout, along with number of organizations supporting the approval of Flibanserin, launched a campaign called “Even the Score”.

“There are 26 FDA approved drugs to treat various sexual dysfunctions for men (41 if you count generics!), but still not a single one for women’s most common sexual complaint,” the campaign argues on its website. “Why do we fast track the approval of drugs like Viagra (1998) for men?”

According to the campaign, sex is “a basic human right” and now is the “time to even the score when it comes to treatment of women’s sexual dysfunction”.

But a coalition of organizations led by the National Women’s Health Network wrote in a letter to the FDA: “The problem with Flibanserin is not gender bias at the FDA but the drug itself.” The group expressed support of the FDA’s “evidence-based evaluation and decision-making”.

Some healthcare experts, including Dr Adriane Fugh-Berman, a professor at Georgetown University, worry about how such campaigns might influence the FDA in the future now that Flibanserin has been approved.

“This may set a precedent of risky drugs being approved based on public relations campaigns rather than science,” she told Marketplace.

“I think whether or not this is ultimately the right choice for women is a story that will be told in the marketplace,” Cindy Whitehead, the chief executive of Sprout, told Fast Company. Whitehead said that developing the drug and getting it approved became “a cause” for her.

Women suffering from HSDD also argue that it’s up to them to determine if the benefits outweigh the risks. Testifying before the FDA in June, a number of them urged the agency to approve the drug.

Amanda Parrish was one of the more than 11,000 women who have participated in Flibanserin’s trial. Prior to joining the trial, she would try to avoid her husband, Ben, come bedtime. After she began taking Flibanserin, she said she did not feel any different during the day but her evenings turned around.

“What it did do was at the end of a long day, no matter how tired I was, I wanted to initiate and it was not work to do that,” she told NBC Nightly News.

“She was flirty again. She was leaving me notes on my bathroom mirror in the morning,” said Ben Parrish. “We know that it works. We experienced it.”

Despite the anecdote at the end, this pill isn't going to turn any women away from pursuing the Eat, Pray, Love fantasy because of some renewed attraction to her schlub of a husband. It should be quite profitable for the pharmaceutical industry though.

Post: #2

more prescription drugs, just what Americans need.

Post: #3

Someone might want to tell them that viagra is an insult to evolution.

*whistles innocently*

Post: #4

Women go to their jobs where they're in charge of men, and ordering them around. Then they come home to their husband cooking dinner and vacuuming the floor. Then they wonder why they need a pill to get turned on.

Post: #5

just strange.

Post: #6

Considering how well 50 shades of grey sold, I don't think women are lacking a sex drive. Might be those blue pills men are popping on a daily basis.

Post: #7

I wonder what effect it produces on males? Does it pump up the seratonin?

Post: #8

The FDA is late to the party, it has already been invented and yields excellent results with the target demographic:

Post: #9

As Celtic_Austrian alludes to.
Women really only have genuine desire for the top ~5% of men...?
So now that desire for the top ~5% of men is potentially boosted by a pill.

Doubt it will help the low status men out there.

Post: #10

Someone needs to spoof this with a YouTube fake commercial. The premise should be: woman takes pill and the perception of her boring husband changes so he seems to be a bad boy.

Maybe the side effect is that so does every other boring guy.

Post: #11

Red wine is the best female viagra and tied with tequila.
Anything that gets the va jay jay hot and wet is the point! No need for a pill.

Post: #12

Can see this being the new date rape drug depending upon how quickly it works.

Post: #13

Dupe-ish: /thread-48033.html

That thread is from 2 months ago when approval was "imminent"

"I'd hate myself if I had that kind of attitude, if I were that weak." - Arnold

Post: #14

(08-18-2015 08:01 PM)poutsara Wrote:  Addyi (flibanserin) is completely different than Viagra (sildenafil) - this comparison is ridiculous and only an ill informed and lazy journalist (or the drug maker going after the money) would describe addyi as a female version of viagara.

Flibanserin acts on the seratonin axis in the brain. They are talking about changing neurotransmitters in the brain by a chemical for the purpose of altering someones sexual behavior. Sildenafil causes vasodilation so that men who can't get erections due to vascular problems can get erections (for example, old men with cardiovascular diseases or diabetes). Sildenafil doesn't directly change your sexual desire or behavior. (Although, men who have erection problems improved by sildenafil may consequently be more confident in sex, but this is not the same things as purposefully altering brain neurotransmitters).

This scares me, actually. Think about it: let's go and change womens sexual behavior by rewiring neurotransmitters with a synthetic drug marketed to them directly. Insane and stupid. Would be equally insane and stupid for men. What a wasted research effort on the part of the drug company. There are real health problems to solve.

(Unrelated note: I am willing to bet that there was a large placebo effect in their trials.)

So the sex drugs for men just briefly alters their bodies, but the "sex drugs" for women have to alter their minds on a daily basis. If that doesn't speak on the nature of sex among men and women, I don't know what does.

Post: #15

Being with an Alpha who knows how to beat the pussy up right is probably all the "viagra" most of these birds need.

This pill will do very little to help them get wet for their beta husbands most likely.

Post: #16

Quote:According to the campaign, sex is “a basic human right” and now is the “time to even the score when it comes to treatment of women’s sexual dysfunction”.

If sex is a basic human rights, then why do women deny 80% of men including their husband/boyfriend sex all the time while only fucking the top 20% alpha? You cant deny someone their basic rights, right?

Way I see it, this "sexual dysfunction" is just another collateral damage from feminism.

Post: #17

(08-18-2015 08:15 PM)Celtic_Austrian Wrote:  The FDA is late to the party, it has already been invented and yields excellent results with the target demographic:

Post: #18

My ex would have been a perfect candidate for this.